Acute epiglottitis and infant conjugate Haemophilus influenzae type b vaccination in northern Finland.
Arch Otolaryngol Head Neck Surg
; 121(8): 898-902, 1995 Aug.
Article
em En
| MEDLINE
| ID: mdl-7619418
ABSTRACT
OBJECTIVE:
To determine the incidence and characteristics of acute epiglottitis among children (< or = 19 years of age) and adults (> or = 20 years of age) before and after widespread conjugate Haemophilus influenzae type b vaccination for infants.DESIGN:
A retrospective population-based survey over a 27-year period from 1967 through 1993 in 35 communities in a northern province of Finland with a population of approximately 300,000.SETTING:
An academic tertiary referral center. MAIN OUTCOMEMEASURES:
All acute epiglottitis cases in the area identified from the hospital discharge register and the regional autopsy register.RESULTS:
The average incidence rate for children was 1.8 cases per 100,000 individuals per year (95% confidence interval [CI], 1.3 to 2.5). As no vaccine failures emerged, the incidence rate for children aged 0 to 4 years declined sharply once the vaccination started in 1986 from 7.6 (95% CI, 5.3 to 10.4) to 0 (95% CI, 0 to 3.3) cases per 100,000 individuals per year. By contrast, a fourfold increase in adult acute epiglottitis (incidence rate ratio, 4.6; 95% CI, 2.7 to 7.9) was detected after vaccination of the children, the average incidence rate for the whole period being 1.0 cases per 100,000 individuals per year (95% CI, 0.8 to 1.3). No marked change in the adult patient profile was found during this increase, however.CONCLUSION:
Acute epiglottitis practically vanished among young children in this population after conjugate H influenzae vaccination, but adult cases increased, the patient profile remaining the same.
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Base de dados:
MEDLINE
Assunto principal:
Haemophilus influenzae
/
Vacinação
/
Vacinas Anti-Haemophilus
/
Epiglotite
/
Infecções por Haemophilus
Tipo de estudo:
Incidence_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Arch Otolaryngol Head Neck Surg
Assunto da revista:
OTORRINOLARINGOLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Finlândia