Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug.
J Clin Psychiatry
; 56 Suppl 6: 3-11, 1995.
Article
em En
| MEDLINE
| ID: mdl-7649970
ABSTRACT
Nefazodone is a new antidepressant drug with a pharmacologic profile distinct from that of the tricyclic, monoamine oxidase inhibitor, and serotonin selective reuptake inhibitor antidepressants. Nefazodone was initially discovered for its ability to block 5-HT2A receptors and its reduced potency as an alpha 1-adrenergic blocker. It was later shown to inhibit both serotonin and norepinephrine uptake in vitro, attributes which most likely impart its clinical efficacy and which differentiate nefazodone from its chemical predecessor trazodone. The combination of these two mechanisms may ultimately result in a facilitation of 5-HT1A-mediated neurotransmission, which may be beneficial for treating symptoms of depression as evidenced by recent clinical findings. In addition, the preclinical profile of nefazodone demonstrates that it has decreased anticholinergic and antihistaminic activity relative to traditional agents. Clinical findings to date are consistent with these observations.
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Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
Antidepressivos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Clin Psychiatry
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos