Concussion-induced retrograde amnesia in rats.
Physiol Behav
; 57(6): 1107-15, 1995 Jun.
Article
em En
| MEDLINE
| ID: mdl-7652031
ABSTRACT
Three experiments were conducted to investigate the characteristics of retrograde amnesia (RA) induced by concussion in rats. In Experiment 1, rats receiving experimental concussion shortly after training in a single punishment trial exhibited severe forgetting on a retention test 48 h later. In the second experiment, rats receiving a concussion within 6 h after training showed severe RA, while those receiving concussion one day to five days after training exhibited progressively weaker amnesia. In Experiment 3, amnesic animals in one group received pretest noncontingent foot shock as a reminder treatment. This pretest cue significantly increased the cross-through latency, thus indicating a reduction in the memory deficit resulting from concussion. These results suggest that experimental concussion can be an effective method to induce retrograde memory loss in rats; that the RA caused by concussion is time-dependent; and that concussion-induced RA can be alleviated by a pretest cue indicating that the underlying mechanism of concussion-induced RA is more likely to be a retrieval deficit than a consolidation failure.
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Base de dados:
MEDLINE
Assunto principal:
Concussão Encefálica
/
Amnésia Retrógrada
Limite:
Animals
Idioma:
En
Revista:
Physiol Behav
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos