Design of specific immunogens using filamentous phage as the carrier.
Gene
; 128(1): 85-8, 1993 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-7685305
ABSTRACT
Earlier, we developed an expression vector allowing exposure of short peptides on the surface of bacteriophage M13. It was used to obtain a recombinant phage carrying an antigenic determinant of HIV1 p17 Gag protein. Immunoglobulin elicited by immunizing rabbits with the phage reacted with the 17-kDa core protein of the virus and with its polyprotein precursor, p55, on Western blots of HIV1 viral proteins. The results of present experiments may be useful in vaccine development.
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Base de dados:
MEDLINE
Assunto principal:
Produtos do Gene gag
/
HIV-1
/
Bacteriófago M13
Limite:
Animals
Idioma:
En
Revista:
Gene
Ano de publicação:
1993
Tipo de documento:
Article