Coley's toxins, tumor necrosis factor and cancer research: a historical perspective.
Pharmacol Ther
; 64(3): 529-64, 1994.
Article
em En
| MEDLINE
| ID: mdl-7724661
ABSTRACT
As far back as the 1700s, it was recorded that certain infectious disease processes could exert a beneficial therapeutic effect upon malignancy. Most prominent among the numerous deliberate efforts made to take advantage of these observations was that of a pioneering New York surgeon, William B. Coley, active career 1891-1936. Using a bacterial vaccine to treat primarily inoperable sarcoma. Coley accomplished a cure rate of better than 10%. This review examines the history of these efforts and presents a discussion of their corresponding relevance to present day immunotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Toxinas Bacterianas
/
Vacinas Bacterianas
/
Fator de Necrose Tumoral alfa
/
Erisipela
/
Imunoterapia
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Pharmacol Ther
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Estados Unidos