Developmentally regulated expression of P-glycoprotein (multidrug resistance) activity in mouse thymocytes.
Eur J Immunol
; 25(5): 1457-60, 1995 May.
Article
em En
| MEDLINE
| ID: mdl-7774650
ABSTRACT
P-glycoprotein (P-gly) is the transmembrane efflux pump responsible for multidrug resistance in tumor cells. The activity of P-gly in mature peripheral lymphocytes is lineage specific, with CD8+ T cells and natural killer (NK) cells expressing high levels as compared to CD4+ T cells and B cells. We have now investigated P-gly activity in immature and mature subsets of mouse thymocytes. Our data indicate that P-gly activity is undetectable in immature CD4-8- and CD4+8+ thymocyte subsets. Among mature thymocytes, P-gly activity is absent in the CD4+ subset but present in the more mature (HSAlow) fraction of CD8+ cells. Furthermore, while thymic CD4-8- T cell receptor (TCR) gamma delta cells have little P-gly activity, a minor subset of CD4-8- or CD4+ TCR alpha beta + thymocytes bearing the NK1.1 surface marker expresses high levels of P-gly activity. Collectively, our results indicate that P-gly activity arises late during thymus development and is expressed in a lineage-specific fashion.
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Base de dados:
MEDLINE
Assunto principal:
Timo
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Subpopulações de Linfócitos T
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Membro 1 da Subfamília B de Cassetes de Ligação de ATP
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Regulação da Expressão Gênica no Desenvolvimento
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Resistência a Múltiplos Medicamentos
Limite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Suíça