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Cytokines in the viviparous reproduction of squamate reptiles: interleukin-1 alpha (IL-1 alpha) and IL-1 beta in placental structures of a skink.
Paulesu, L; Romagnoli, R; Marchetti, M; Cintorino, M; Ghiara, P; Guarino, F M; Ghiara, G.
Afiliação
  • Paulesu L; Institute of General Physiology, University of Siena, Italy.
Placenta ; 16(2): 193-205, 1995 Mar.
Article em En | MEDLINE | ID: mdl-7792282
Placental viviparity is known in many species of squamate reptiles. Among these, some scincids have developed an epithelio-chorial chorio-allantoic placenta which in the structure of its central ridged zone is similar to those of certain therian mammalian species. A broad range of immunoregulatory peptides, cytokines, has been identified at the maternofetal interface of several species of mammals, either with invasive or non-invasive types of placenta. Thus we began to study whether interleukin-1, which is considered to play a crucial role in mammalian pregnancy, might also be involved in the viviparity of reptilian species. Placentae of Chalcides chalcides L. were processed by immunohistochemistry and incubated in a culture medium for different times. A very strong immunoreactivity for interleukin-1 alpha (IL-1 alpha) and for interleukin-1 beta (IL-1 beta) was present in the chorial epiblast and in uterine epithelial cells, with varying degree and localization in different periods of pregnancy. IL-1 beta was also released into the medium at different amounts during incubation. In light of the mammalian data, our results suggest that the role of cytokines in pregnancy may represent a significant event in the evolution of placental viviparity.
Assuntos
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Base de dados: MEDLINE Assunto principal: Placenta / Reprodução / Interleucina-1 / Lagartos Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Revista: Placenta Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Itália
Buscar no Google
Base de dados: MEDLINE Assunto principal: Placenta / Reprodução / Interleucina-1 / Lagartos Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Revista: Placenta Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Itália