NGF stimulates differentiation of osteoblastic MC3T3-E1 cells.
Biochem Biophys Res Commun
; 205(2): 1187-93, 1994 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-7802649
ABSTRACT
The activities of NGF on induction of IL-6, ALP and collagen were studied in cultured osteoblastic cells, MC3T3-E1. Treatment of the cells with NGF induced IL-6 production in a dose dependent manner and enhanced ALP activity and collagen biosynthesis without affecting cell proliferation. Cyclo-oxygenase was activated in NGF-treated cells and prostaglandinE2 was detected as a major metabolite from arachidonic acid. Since prostaglandinE2 is an enhancer of ALP activity and collagen biosynthesis in MC3T3-E1 and was found to induce IL-6 production in this study, it is possible that NGF works on MC3T3-E1 cells through the mediation by endogenous prostaglandinE2.
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Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
/
Interleucina-6
/
Fatores de Crescimento Neural
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Japão