Activities of antioxidant enzymes in various tissues of male Fischer 344 rats are altered by food restriction.
J Nutr
; 125(2): 195-201, 1995 Feb.
Article
em En
| MEDLINE
| ID: mdl-7861246
ABSTRACT
The objective of this study was to determine how food restriction (40% restriction of food intake) altered the age-related changes in the activities of Cu,Zn superoxide dismutase, catalase and glutathione peroxidase in liver, brain cortex, heart, kidney and intestinal mucosa obtained from 6-, 16- and 26-mo-old male Fischer 344 rats. Food restriction increased the activity of one or more of the antioxidant enzymes in the liver, brain cortex, heart and kidney of the rats. However, the magnitude of the effect and the antioxidant enzyme(s) affected by food restriction varied from tissue to tissue, and food restriction had no significant effect on the activities of these enzymes in intestinal mucosa. Interestingly, the four tissues in which food restriction increased the activity of one or more of the antioxidant enzymes showed reduced lipid peroxidation as measured by thiobarbituric acid-reactive material. These data suggest that food restriction might enhance the survival of rodents by altering the levels of the antioxidant enzymes and hence reducing free radical damage.
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Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
/
Catalase
/
Privação de Alimentos
/
Glutationa Peroxidase
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
J Nutr
Ano de publicação:
1995
Tipo de documento:
Article