Treatment of beta-thalassemia with hydroxyurea (HU)--effects of HU on globin gene expression.
Sci China B
; 37(11): 1350-9, 1994 Nov.
Article
em En
| MEDLINE
| ID: mdl-7865126
ABSTRACT
A newly developed method of RT-PCR/competitive PCR for measuring the relative and absolute content of globin mRNAs as well as micro-globin chain biosynthetic assay have been used to study the alterations of globin gene expressions in the patients with beta-thalassemia pre- and post-hydroxyurea (HU) treatment. It was found for the first time that HU had the effect of enhancing beta-globin gene expression in some patients. Two cases with beta-thalassemia who were subjected to HU treatment for over two years showed a marked increase in beta-globin mRNA level and beta-globin chain synthesis, resulting in more effective erythropoiesis and the alleviation of clinical symptoms.
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Base de dados:
MEDLINE
Assunto principal:
Globinas
/
RNA Mensageiro
/
Talassemia beta
/
Hidroxiureia
Limite:
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Sci China B
Assunto da revista:
BIOLOGIA
/
CIENCIA
/
QUIMICA
Ano de publicação:
1994
Tipo de documento:
Article