Assessment of proliferating-cell nuclear antigen immunostaining in soft-tissue tumours: relationship to histological grade and mitotic activity.
J Cancer Res Clin Oncol
; 120(7): 393-8, 1994.
Article
em En
| MEDLINE
| ID: mdl-7910610
ABSTRACT
The proliferative activity in 70 cases of soft-tissue tumours was estimated immunohistochemically using the monoclonal antibody PC-10, which recognizes proliferating-cell nuclear antigen (PCNA) in paraffin sections. The PCNA index (i.e. the percentage of positive neoplastic nuclei) and to a lesser degree the PCNA count (i.e. the number of positive neoplastic nuclei per ten high-power fields) positively correlated with the malignancy grade (PCNA index P < 0.001; PCNA count P < 0.01). However, the range of values of PCNA index and PCNA count was similar between benign and grade I tumours. A statistically significant positive correlation was also established between PCNA index and PCNA count on the one hand and mitotic count on the other, but the correlation coefficient was low (r = 0.351, P < 0.01, and r = 0.290, P < 0.05 respectively). These results indicate that PCNA immunostaining may successfully be used as an adjunct to the conventional histopathological parameters in assessing the malignancy grade in soft-tissue tumours although it is of limited value in distinguishing between benign and grade I tumours.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias de Tecidos Moles
/
Proteínas Nucleares
Idioma:
En
Revista:
J Cancer Res Clin Oncol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Grécia