Synthesis and topical antiinflammatory and antiallergic activities of antioxidant o-aminophenol derivatives.
J Med Chem
; 37(13): 1977-82, 1994 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-7913134
ABSTRACT
In order to develop novel compounds for topical use possessing antiallergic as well as antiinflammatory activities, a series of o-aminophenol derivatives bearing H1-antihistaminic structures were synthesized and their effects were investigated on lipid peroxidation in rat brain homogenates, antiinflammatory effection arachidonic acid- and 12-O-tetradecanoylphorbol-13- acetate-induced mouse ear edema and antiallergic effect on 48-h homologous passive cutaneous anaphylaxis in rats. Furthermore, the effects of these compounds on delayed-type hypersensitivity reaction in mice were examined. Several N-monosubstituted amino-4-methylphenols were found to exert potent inhibitory activities in all of these assays. Of these compounds, 4m was chosen for further development as AD0261.
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Base de dados:
MEDLINE
Assunto principal:
Anafilaxia Cutânea Passiva
/
Peroxidação de Lipídeos
/
Anti-Inflamatórios não Esteroides
/
Aminofenóis
/
Antagonistas dos Receptores Histamínicos H1
/
Hipersensibilidade Tardia
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Japão