Effects of dextran-linked chloromercuribenzoic acid on insulin release from microdissected pancreatic islets.
Biochim Biophys Acta
; 451(1): 96-105, 1976 Nov 18.
Article
em En
| MEDLINE
| ID: mdl-795463
ABSTRACT
Insulin release in response to dextran-linked p-chloromercuribenzoic acid was studied in microdissected pancreatic islets of non-inbred ob/ob-mice. No contamination of the dextran-linked mercurial with free chloromercuribenzoic acid was detected before or after the incubation with islets. In comparison with free mercurial, of the same thiol-blocking activity, the dextran-linked compound had a weak insulin-releasing action with a different dose vs. response relationship. The dextran-linked mercurial had no demonstrable effect on the islet content of cyclic AMP. The results support the hypothesis that free organic mercurials mainly stimulate insulin release by blocking thiol ground that are embedded within the beta-cell plasma membranes beneath their surfaces.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Cloromercurobenzoatos
/
Ilhotas Pancreáticas
/
Dextranos
/
Insulina
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1976
Tipo de documento:
Article