Enhanced rectal absorption of itazigrel formulated with polysorbate 80 micelle vehicle in rat: role of co-administered esterase.
J Pharm Pharmacol
; 46(7): 608-11, 1994 Jul.
Article
em En
| MEDLINE
| ID: mdl-7996393
ABSTRACT
We investigated the effect of esterase on rectal absorption in the rat of itazigrel using polysorbate 80 (PS-80) micelle as a vehicle to overcome the poor aqueous solubility of itazigrel. The itazigrel formulation prepared with PS-80 increased the absorption compared with a 0.25% carmellose sodium suspension, probably by supplying the itazigrel solute to keep a high concentration at the epithelial surface. When esterase was co-administered with the formulations containing PS-80, the absorption of itazigrel from rat rectum was accelerated further, by rapid release of itazigrel from the micelle vehicle after enzymatic degradation of the PS-80 micelle.
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Base de dados:
MEDLINE
Assunto principal:
Polissorbatos
/
Reto
/
Tiazóis
/
Esterases
/
Fibrinolíticos
Limite:
Animals
Idioma:
En
Revista:
J Pharm Pharmacol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Japão