The interaction of glycosaminoglycans with heparin cofactor II.
Ann N Y Acad Sci
; 714: 21-31, 1994 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-8017769
ABSTRACT
The binding sites for dermatan sulfate and heparin in HCII overlap but are not identical. This may explain the observation that HCII binds nonspecifically to heparin oligosaccharides, but preferentially binds to a minor hexasaccharide isolated from dermatan sulfate. The tissue distribution of dermatan sulfate molecules containing the high-affinity HCII binding site may regulate HCII activity in vivo. Finally, in the presence of dermatan sulfate or heparin, the N-terminal acidic region of HCII may interact with the hirudin-binding site of thrombin to produce maximal stimulation of the thrombin-HCII reaction.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Conformação Proteica
/
Trombina
/
Cofator II da Heparina
/
Glicosaminoglicanos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
1994
Tipo de documento:
Article