Determination of diclofenac sodium, famotidine and ketorolac tromethamine by flow injection analysis using dichloronitrophenol.
J Pharm Biomed Anal
; 12(3): 343-6, 1994 Mar.
Article
em En
| MEDLINE
| ID: mdl-8031933
ABSTRACT
Diclofenac sodium, famotidine and ketorolac tromethamine were determined by flow injection analysis (FIA) with spectrophotometric detection. The sample solutions (5-50 micrograms ml-1 of diclofenac sodium, 10-80 micrograms ml-1 of famotidine and 10-120 micrograms ml-1 of ketorolac tromethamine) in methanol were injected into a flow system containing 0.01% (w/v) of 2,4,dichloro-6-nitrophenol (DCNP) in methanol. The colour produced due to the formation of a charge transfer complex was measured with a spectrophotometric detector set at 450 nm. A sampling rate of 40 per hour was achieved with high reproducibility of measurements (RSD below 1.6%). The FIA method was applied to the determination of diclofenac sodium, famotidine and ketorolac tromethamine in pharmaceutical formulations.
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Base de dados:
MEDLINE
Assunto principal:
Trometamina
/
Famotidina
/
Tolmetino
/
Diclofenaco
/
Análise de Injeção de Fluxo
/
Inibidores de Ciclo-Oxigenase
Idioma:
En
Revista:
J Pharm Biomed Anal
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Índia