A monoclonal antibody to human angiogenin suppresses tumor growth in athymic mice.
Cancer Res
; 54(17): 4576-9, 1994 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-8062244
ABSTRACT
Human angiogenin, a potent inducer of neovascularization, is secreted by HT-29 colon adenocarcinoma cells. microgram doses of a monoclonal antibody that neutralizes the in vitro and in vivo activities of angiogenin prevent or delay the appearance of s.c. HT-29 tumors in athymic mice in a statistically significant, dose-dependent manner. The antibody is not cytotoxic to tumor cells in vitro, which indicates that inhibition of tumor growth most likely occurs by neutralization of the activity of angiogenin in vivo and further implies a critical role for angiogenin in the early development of HT-29 tumors. The results suggest a therapeutically useful approach to the treatment of angiogenin-dependent malignancy.
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Base de dados:
MEDLINE
Assunto principal:
Ribonuclease Pancreático
/
Imunoglobulina G
/
Adenocarcinoma
/
Proteínas
/
Neoplasias do Colo
/
Anticorpos Monoclonais
Limite:
Animals
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1994
Tipo de documento:
Article