Renin and angiotensin-converting enzyme genotypes in patients with essential hypertension and left ventricular hypertrophy.
Clin Exp Pharmacol Physiol
; 21(3): 207-10, 1994 Mar.
Article
em En
| MEDLINE
| ID: mdl-8076423
ABSTRACT
1. The associations between left ventricular hypertrophy (LVH) and specific alleles of the renin and angiotensin-converting enzyme (ACE) genes were studied in patients with essential hypertension and normal blood pressure. 2. LVH was present in 42% of those with essential hypertension (n = 72) and 17% of those with normal blood pressure (n = 44). 3. The frequency of each renin allele was the same in hypertensive and in normotensive patients. Renin allele frequencies were also the same for those with LVH and those with normal cardiac mass. When only hypertensives were considered, renin alleles were in the same proportion for the groups with and without LVH. Similarly, ACE alleles were not associated with essential hypertension nor with elevated cardiac mass. 4. We conclude that, in this population, variations in the renin or ACE genes do not contribute significantly to the development of LVH or to essential hypertension.
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Base de dados:
MEDLINE
Assunto principal:
Renina
/
Hipertrofia Ventricular Esquerda
/
Peptidil Dipeptidase A
/
Hipertensão
Limite:
Humans
Idioma:
En
Revista:
Clin Exp Pharmacol Physiol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Austrália