Buspirone treatment of anxious alcoholics. A placebo-controlled trial.
Arch Gen Psychiatry
; 51(9): 720-31, 1994 Sep.
Article
em En
| MEDLINE
| ID: mdl-8080349
ABSTRACT
BACKGROUND:
Symptoms of anxiety are common in alcoholics and may contribute to relapse following initiation of abstinence. Buspirone hydrochloride, a serotonin1A partial agonist, has a pharmacologic profile that may be particularly suited to the treatment of anxious alcoholics.METHODS:
We conducted a randomized, 12-week, placebo-controlled trial of buspirone in 61 anxious alcoholics, all of whom also received weekly relapse prevention psychotherapy. Outcomes were measured at the end of treatment and at a 6-month follow-up evaluation.RESULTS:
Buspirone therapy was associated with greater retention in the 12-week treatment trial, reduced anxiety, a slower return to heavy alcohol consumption, and fewer drinking days during the follow-up period.CONCLUSIONS:
Buspirone appears to have a useful role in the treatment of anxious alcoholics. Further research is needed to clarify which patient characteristics and concomitant treatments result in optimal response to buspirone therapy.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos de Ansiedade
/
Buspirona
/
Alcoolismo
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arch Gen Psychiatry
Ano de publicação:
1994
Tipo de documento:
Article