PHA-stimulated cellular immune function and T-lymphocyte subsets in major depressive disorders.
Funct Neurol
; 9(1): 17-22, 1994.
Article
em En
| MEDLINE
| ID: mdl-8082849
ABSTRACT
We measured some immunological parameters in 20 hospitalized patients with major depression and 20 age- and sex-matched healthy controls. Both enumeration of immune cells, including T-lymphocyte subpopulations, and assay of T-cell function were studied. White blood cells were evaluated with an automated cell counter, T-cell subsets with an immunobead technique, and T-cell function with a phytohemagglutinin-induced proliferation in vitro assay. We found that T-lymphocyte responses to the mitogen were significantly lower in depressed patients than in controls. All the other parameters were normal. These findings suggest that functional but not numerical changes in T-lymphocytes characterize major depressive disorders.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Fito-Hemaglutininas
/
Ativação Linfocitária
/
Subpopulações de Linfócitos T
/
Transtorno Depressivo
/
Imunidade Celular
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Funct Neurol
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Itália