Effects of rokitamycin on bilirubin-albumin binding: a study in vitro.

ABSTRACT

The effects of rokitamycin, a macrolide antibiotic, on the binding of bilirubin to albumin were examined in vitro using blood plasma from young rats with hyperbilirubinemia, bilirubin-supplemented serum separated from human cord blood, and the human serum from a newborn infant with icterus gravis neonatorum. Rokitamycin at concentrations from 1 to 500 micrograms/ml (the entire range over which experiments could be conducted) had little or no effect on the concentration of unbound bilirubin in any of the incubation mixtures used. This result suggests that rokitamycin has no effect on the binding of bilirubin to albumin.