Immunological dissection of human Ia molecules.
J Exp Med
; 148(6): 1592-611, 1978 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-82605
ABSTRACT
The immunochemical analysis of Daudi Ia molecules by a variety of alloantisera led to the recognition of at least three molecular species carrying different antigenic determinants DRw6, DC-1, and DC-2. Genetic as well as structural evidence indicates that DRw6 and DC-1 molecules are controlled by separate, HLA-linked loci, rather than by alleles at the same locus. The alloantigenic determinants appear to be expressed on the small Ia subunit. DC-1 and DC-2 determinants discussed had not been defined by serological analysis at the population level, but were demonstrated to be present by immunochemical analysis at the molecular level.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Isoantígenos
/
Complexo Principal de Histocompatibilidade
/
Antígenos de Superfície
Limite:
Humans
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1978
Tipo de documento:
Article