[The adaptive response of B cells to the action of cytotoxic preparations in culture. III. The possible mechanism of the action of adriamycin on immunoglobin synthesis by the cells of murine myeloma]. / Adaptivnyi otvet B-kletok na deistvie tsitotoksicheskikh preparatov v kul'ture III. Vozmozhnyi mekhanizm vliianiia adriamitsina na sintez immunoglobulinov kletkami myshinoi mielomy.
Tsitologiia
; 35(6-7): 98-104, 1993.
Article
em Ru
| MEDLINE
| ID: mdl-8266570
ABSTRACT
A dose-dependent stimulation of immunoglobulin synthesis by Spebr-5 cells in the presence of adriamycin is shown. This effect is significantly blocked in the presence of iron-chelating agent 2,2-bipyridine. Moreover, low doses of H2O2 and heat shock also caused enhancement of immunoglobulin synthesis. These data suggest the involvement of free radical processes in the adriamycin induced stimulation of immunoglobulin synthesis.
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Base de dados:
MEDLINE
Assunto principal:
Imunoglobulinas
/
Adaptação Fisiológica
/
Doxorrubicina
/
Mieloma Múltiplo
Limite:
Animals
Idioma:
Ru
Revista:
Tsitologiia
Ano de publicação:
1993
Tipo de documento:
Article