Mos and the cell cycle: the molecular basis of the transformed phenotype.
Curr Opin Genet Dev
; 3(1): 19-25, 1993 Feb.
Article
em En
| MEDLINE
| ID: mdl-8384034
ABSTRACT
The product of the mos proto-oncogene is a serine/threonine kinase that is expressed at high levels in germ cells. Mos is a regulator of meiotic maturation, and is required for the initiation and progression of oocyte meiotic maturation that leads to the production of unfertilized eggs. Mos is also a component of cytostatic factor, an activity that is believed to arrest oocyte maturation at meiotic metaphase II. There is evidence showing that the Mos protein is associated with tubulin in unfertilized eggs and transformed cells, raising the possibility that it is involved in the microtubular reorganization that occurs during M-phase. Inappropriate expression of its M-phase activity during interphase of the cell cycle may be responsible for its transforming activity.
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Base de dados:
MEDLINE
Assunto principal:
Proto-Oncogenes
/
Ciclo Celular
/
Transformação Celular Neoplásica
/
Proteínas Proto-Oncogênicas c-mos
/
Proteínas Oncogênicas v-mos
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Curr Opin Genet Dev
Assunto da revista:
GENETICA
Ano de publicação:
1993
Tipo de documento:
Article