The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human chromosome 4q.
Nat Genet
; 4(4): 410-4, 1993 Aug.
Article
em En
| MEDLINE
| ID: mdl-8401591
ABSTRACT
The autosomal Booroola fecundity gene (FecB) mutation in sheep increases ovulation rate and litter size, with associated effects on ovarian physiology and hormone profiles. Analysis of segregation in twelve families (379 female progeny) identified linkage between the mutation, two microsatellite markers (OarAE101 and OarHH55, Zmax > 9.0) and epidermal growth factor (EGF) from human chromosome 4q25 (Zmax > 3.0). The marker OarAE101 was linked to secreted phosphoprotein 1 (SPP1, which maps to chromosome 4q21-23 in man) in the test pedigrees and independent families (Zmax > 9.7). The identification of linkage between the FecB mutation and markers from human chromosome 4q is an important step towards further understanding the control of ovulation rates in mammals.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 4
/
Ovinos
/
Mapeamento Cromossômico
/
Fertilidade
/
Mutação
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nat Genet
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Nova Zelândia