DFMO reduces cortical infarct volume after middle cerebral artery occlusion in the rat.
J Cereb Blood Flow Metab
; 13(6): 1033-7, 1993 Nov.
Article
em En
| MEDLINE
| ID: mdl-8408313
ABSTRACT
Ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is induced in ischemic tissue and may mediate vasogenic edema and delayed neuronal death. We determined the effects of alpha-difluoromethylornithine (DFMO), a specific inhibitor of ODC, on infarct size and ODC activity in a rat model of transient focal ischemia. DFMO blocked the ischemia-induced increase in ODC and significantly reduced infarct volumes by 57-45%, depending upon the treatment regimen. These studies suggest that polyamine metabolism plays a role in the development of cerebral infarction after focal ischemia and that DFMO may be useful in limiting injury after a stroke.
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Base de dados:
MEDLINE
Assunto principal:
Ornitina Descarboxilase
/
Infarto Cerebral
/
Ataque Isquêmico Transitório
/
Eflornitina
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Ano de publicação:
1993
Tipo de documento:
Article