Body-composition changes in patients who gain weight while receiving megestrol acetate.
J Clin Oncol
; 11(1): 152-4, 1993 Jan.
Article
em En
| MEDLINE
| ID: mdl-8418227
ABSTRACT
PURPOSE:
Randomized placebo-controlled clinical trials have now established that megestrol acetate causes appetite stimulation and weight gain in patients with anorexia and/or cachexia. There is a paucity of available data to delineate the substance of this increased weight. PATIENTS ANDMETHODS:
Using dual-energy x-ray absorptiometry and tritiated body water methodologies, we performed body-composition measurements in 12 patients with advanced cancer before the institution of oral megestrol acetate (800 mg/d) and at subsequent 2-month intervals.RESULTS:
Seven of the 12 patients gained weight (2.1 to 16.5 kg) and had repeat body-composition measurements performed at the time of maximum weight gain. The vast majority of the gained weight was clearly from an increase in adipose tissue, while there was a suggestion that an increase in body fluid was responsible for a minority of the weight gain.CONCLUSION:
Megestrol acetate-induced weight gain is primarily the result of an increase in body mass.
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Base de dados:
MEDLINE
Assunto principal:
Composição Corporal
/
Peso Corporal
/
Megestrol
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Oncol
Ano de publicação:
1993
Tipo de documento:
Article