Naturally occurring deuterium is essential for the normal growth rate of cells.
FEBS Lett
; 317(1-2): 1-4, 1993 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-8428617
ABSTRACT
The role of naturally occurring D in living organisms has been examined by using deuterium-depleted water (30-40 ppm D) instead of water containing the natural abundance of D (150 ppm). The deuterium-depleted water significantly decreased the growth rate of the L929 fibroblast cell line, and also inhibited the tumor growth in xenotransplanted mice. Eighty days after transplantation in 10 (59%) out of 17 tumorous mice the tumor, after having grown, regressed and then disappeared. We suggest that the naturally occurring D has a central role in signal transduction involved in cell cycle regulation.
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Base de dados:
MEDLINE
Assunto principal:
Divisão Celular
/
Deutério
Limite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Hungria