Novel sequences conserved on the human and mouse X chromosomes.
Genomics
; 15(3): 483-91, 1993 Mar.
Article
em En
| MEDLINE
| ID: mdl-8468042
ABSTRACT
We have cloned and mapped 28 single-copy probes from a pool of cosmids derived from the human X chromosome. Four of the probes detected strongly conserved sequences in murine DNA; all have been localized to the proximal region of the human X chromosome short arm. Comparative mapping of these sequences in the mouse genome demonstrates that, while X linkage is conserved, this region of the human X chromosome is not maintained as a contiguous segment on the mouse X chromosome. The mapping of one novel conserved sequence between Plp and Pdha1 on the mouse X chromosome defines a previously unknown region of homology. The mapping of another probe that detects a novel sequence family (DXF34) close to the X chromosome centromere in both species suggests that a block of pericentromeric material is conserved between the X chromosomes of man and mouse.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomo X
/
Sequência Conservada
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Genomics
Assunto da revista:
GENETICA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Reino Unido