Catecholamine metabolism during heroin use.
Am J Psychiatry
; 134(5): 534-7, 1977 May.
Article
em En
| MEDLINE
| ID: mdl-848581
ABSTRACT
The authors examined urinary levels of catecholamines and metabolites during a 10-day period of heroin use in 9 subjects. Catecholamine and metabolite excretion increased over baseline values on the first day of heroin use, but markedly different patterns of change emerged later. In contrast to the significant increase in normetanephrine and decrease in metanephrine excretion in all 9 subjects during heroin use, only 4 subjects showed an increase in 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion. Moreover, it appeared that the increase in MHPG excretion in this subgroup began on the day before heroin administration, which suggests the possibility of an anticipatory or conditioned response.
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Base de dados:
MEDLINE
Assunto principal:
Catecolaminas
/
Dependência de Heroína
Limite:
Humans
Idioma:
En
Revista:
Am J Psychiatry
Ano de publicação:
1977
Tipo de documento:
Article