Hexasomy of chromosome 8 and trisomy of chromosome 11 characterize two karyotypically independent clones in a case of acute non-lymphocytic leukemia. Conventional cytogenetic and FISH investigation.
Cancer Genet Cytogenet
; 85(1): 1-4, 1995 Nov.
Article
em En
| MEDLINE
| ID: mdl-8536231
ABSTRACT
A case of ANLL following a myelodysplastic syndrome, probably resulting from occupational exposure to ionizing irradiation, with two cytogenetically unrelated clones, hexasomy 8 and trisomy 11, was investigated by conventional cytogenetics and FISH. Significant quantitative differences between data obtained by metaphase and interphase analysis of the hexasomy 8 clone were observed. A difference in the sensitivity to chemotherapy of the two clones was found while the hexasomy 8 clone markedly decreased in response to treatment, the trisomy 11 clone remained unchanged.
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Base de dados:
MEDLINE
Assunto principal:
Trissomia
/
Cromossomos Humanos Par 8
/
Cromossomos Humanos Par 11
/
Leucemia Mieloide Aguda
/
Aneuploidia
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Israel