DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.
Science
; 271(5247): 350-3, 1996 Jan 19.
Article
em En
| MEDLINE
| ID: mdl-8553070
ABSTRACT
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4, a gene similar in sequence to a Drosophila melanogaster gene (Mad) implicated in a transforming growth factor-beta (TGF-beta)-like signaling pathway. Potentially inactivating mutations in DPC4 were identified in six of 27 pancreatic carcinomas that did not have homozygous deletions at 18q21.1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Cromossomos Humanos Par 18
/
Proteínas
/
Transativadores
/
Genes Supressores de Tumor
/
Proteínas de Ligação a DNA
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos