Selective regulation of steroid receptor expression in MCF-7 breast cancer cells by a novel member of the heregulin family.
Biochem Biophys Res Commun
; 217(3): 1271-8, 1995 Dec 26.
Article
em En
| MEDLINE
| ID: mdl-8554586
ABSTRACT
A 52 kDa heregulin secreted by estrogen receptor (ER)-negative human breast cancer cells induced rapid growth of ER-positive MCF-7 breast cancer cells with a stimulatory effect observed at 10(-11)M. This heregulin down-regulated the message for ER in MCF-7 cells within 24 hours after stimulation. Similarly the ER protein was down-regulated within 24 to 48 hours after stimulation of cells. However, this down-regulation occurred without activation of the ER, since the progesterone receptor (PR) level of cells stimulated with the 52 kDa heregulin did not increase over the time period measured. As a control, estradiol down-regulated and activated ER as shown by a pronounced increase in PR content of MCF-7 cells. This finding indicates an important role of this heregulin in the down-regulation of ER in estrogen-dependent human breast cancer cells.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Glicoproteínas
/
Receptores de Progesterona
/
Receptores de Estrogênio
/
Substâncias de Crescimento
Limite:
Female
/
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
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