Modifying toxicokinetics with antidotes.
Toxicol Lett
; 82-83: 785-93, 1995 Dec.
Article
em En
| MEDLINE
| ID: mdl-8597143
ABSTRACT
Five approaches may be described through which antidotes can modify toxicokinetics (1) Decreased bioavailability of the toxins; (2) Cellular redistribution of the toxin in the organism; (3) Promotion of elimination in an unchanged form; (4) Slowing of metabolic activation pathways; (5) Acceleration of metabolic deactivation pathways. However, the ability to modify toxicokinetics with a new treatment, while demonstrating an understanding of the mechanism of action, must never be construed to be, in and of itself, the goal of therapy. The ultimate evaluation of an antidote modifying toxicokinetics is strictly clinical.
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Base de dados:
MEDLINE
Assunto principal:
Toxicologia
/
Farmacocinética
/
Antídotos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
França