Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter.
Biochim Biophys Acta
; 1305(1-2): 34-8, 1996 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-8605246
ABSTRACT
Complementary DNA clones encoding the rat PepT1 small-intestinal oligopeptide transporter were isolated from a jejunal library by cross-hybridization with a rabbit PepT1 cDNA probe. The cDNA sequence indicates that rat PepT1 is composed of 710 amino acids and shows 77% and 83% amino acid sequence identity with rabbit and human PepT1, respectively. Northern blot analysis detected rat PepT1 mRNA in the small intestine and kidney. Intestinal PepT1 mRNA levels were highest in 4-day old rats, and then decreased reaching the adult level by day 28 after birth. These results indicate that the expressions of PepT1 gene change markedly during development.
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Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Proteínas de Transporte
/
Simportadores
/
Intestino Delgado
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão