Enhanced degradation of EGF receptors by a sorting nexin, SNX1.
Science
; 272(5264): 1008-10, 1996 May 17.
Article
em En
| MEDLINE
| ID: mdl-8638121
ABSTRACT
The vectorial movement of proteins requires specific recognition by components of the vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code. SNX1 contains a region of homology to a yeast vacuolar sorting protein, and overexpression of SNX1 decreased the amount of EGFR on the cell surface as a result of enhanced rates of constitutive and ligand-induced degradation. Thus, SNX1 is likely to play a role in sorting EGFR to lysosomes.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Membrana Celular
/
Proteínas de Transporte Vesicular
/
Receptores ErbB
/
Lisossomos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos