Clozapine is a partial agonist at cloned, human serotonin 5-HT1A receptors.
Neuropharmacology
; 35(1): 119-21, 1996 Jan.
Article
em En
| MEDLINE
| ID: mdl-8684591
Clozapine exhibited 10-fold higher affinity than haloperidol for human 5-HT1A receptors expressed in Chinese Hamster Ovary cells (CHO-h5-HT1A) (Kis = 160 and 1910 nM respectively). Whereas haloperidol did not alter the basal binding of [35S]GTP gama S to CHO-h5HT1A membranes, clozapine stimulated it with an EC50 of 2320 nM and an efficacy of 49% (compared to 5-HT). The stimulation was antagonized by the selective 5-HT1A receptor antagonist, WAY 100635 (1 nM).
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Serotonina
/
Clozapina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neuropharmacology
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França