Beta-1,2-linked oligomannosides inhibit Candida albicans binding to murine macrophage.
J Leukoc Biol
; 60(1): 81-7, 1996 Jul.
Article
em En
| MEDLINE
| ID: mdl-8699128
ABSTRACT
Interaction of Candida albicans with cells of the macrophage lineage was examined by using heat-killed (HK) and live yeast cells. Laminarin, an analogue of the cell wall beta-glucans, strongly inhibited HK yeasts adherence to J774 cell line but had no effect on live yeast binding. Phosphopeptidomannan (PPM) from Saccharomyces cerevisiae had a limited effect on the binding of both HK and live yeasts but significant inhibition was achieved by the use of C. albicans PPM. The role of beta-1,2-oligomannosides was examined with regard to their exclusive presence within C. albicans PPM. PPM acid labile beta-1,2-oligomannosides or a synthetic beta-1,2-mannotetraose, inhibited yeasts binding in a manner comparable to the original PPM. These latter results were confirmed by using mouse peritoneal macrophages, thus suggesting a general role for beta-1,2-oligomannosides in the adherence of the yeast to the macrophage membrane.
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Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Fagocitose
/
Candida albicans
/
Macrófagos
Limite:
Animals
Idioma:
En
Revista:
J Leukoc Biol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França