A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression.
Cancer Res
; 56(16): 3711-5, 1996 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-8706012
ABSTRACT
Mechanisms of cancer prevention were studied using structurally different cancer-preventive agents, sarcophytol A, canventol, (-)-epigallo-catechin gallate, and tamoxifen, based on our evidence that tumor necrosis factor alpha (TNF-alpha) acts as an endogenous tumor promoter relevant to human carcinogenesis. Pretreatment with the four preventive agents commonly inhibited TNF-alpha mRNA expression and TNF-alpha release in BALB/3T3 cells induced by a tumor promoter, okadaic acid, whereas the expression of early response genes (c-jun, junB, c-fos, and fosB) was enhanced. These results strongly suggest that inhibition of TNF-alpha mRNA expression and its release is a new process of cancer prevention.
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Base de dados:
MEDLINE
Assunto principal:
Fator de Necrose Tumoral alfa
/
Anticarcinógenos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão