Iodine-123-MIBG imaging in pheochromocytoma with cardiomyopathy and pulmonary edema.
J Nucl Med
; 37(8): 1361-4, 1996 Aug.
Article
em En
| MEDLINE
| ID: mdl-8708774
ABSTRACT
We encountered a patient with pheochromocytoma associated with a catecholamine-induced cardiomyopathy that developed recurrently bilateral and unilateral pulmonary edema. The diagnosis of pheochromocytoma was made by elevated plasma catecholamine levels and the intense tumor [123I]MIBG uptake and was confirmed at the time of surgery. The patient showed reduced myocardial [123I]MIBG uptake with left ventricular dysfunction, and endomyocardial biopsy findings were consistent with the diagnosis of catecholamine-induced cardiomyopathy. After tumor resection, plasma levels of catecholamine were normalized, and pulmonary edema never recurred, although cardiac dysfunction did not show an improvement on echocardiography. Myocardial and lung [123I]MIBG uptake increased when compared to uptake levels on preoperative scans, but myocardial uptake was still below normal. These findings indicated that over-secreted catecholamines influenced both the heart and lungs. Pheochromocytoma can induce cardiac and lung injuries, and [123I]MIBG scanning may contribute not only to tumor characterization but also to assessing and monitoring the influence of catecholamines on the heart and lungs.
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Base de dados:
MEDLINE
Assunto principal:
Feocromocitoma
/
Edema Pulmonar
/
Neoplasias das Glândulas Suprarrenais
/
Radioisótopos do Iodo
/
Iodobenzenos
/
Cardiomiopatias
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
J Nucl Med
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão