A new improved sub-unit vaccine for plague: the basis of protection.
FEMS Immunol Med Microbiol
; 12(3-4): 223-30, 1995 Dec.
Article
em En
| MEDLINE
| ID: mdl-8745007
ABSTRACT
In this study, we have determined the limit of protection achievable by immunisation with sub-units of Yersinia pestis against the development of plague in an experimental animal model. Co-immunisation with the purified culture-derived F1 and the recombinant V sub-units afforded a greater level of protection than with either sub-unit alone. The protection given by the combined sub-units was several orders of magnitude greater than that afforded by the whole cell killed (Cutter USP) vaccine and was equivalent to that achieved by vaccination with EV76, the live attenuated Y. pestis vaccine strain. However, the combined sub-unit vaccine has clear advantages over the live vaccine in terms of safety of use and absence of side-effects.
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Base de dados:
MEDLINE
Assunto principal:
Peste
/
Yersinia pestis
/
Vacinas Sintéticas
/
Vacina contra a Peste
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
FEMS Immunol Med Microbiol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Reino Unido