Cytokine inhibition preserves renal hemodynamic function following mesangial cell immune injury.
J Investig Med
; 44(6): 375-81, 1996 Aug.
Article
em En
| MEDLINE
| ID: mdl-8795301
ABSTRACT
BACKGROUND:
We assessed the effect of a cytokine inhibitor, compound SKF 86002 (a bicyclic imidazole), on changes in renal hemodynamics (renal blood flow and glomerular filtration rate) that occur acutely following immune injury of glomerular mesangial cells.METHODS:
Injury was induced in Munich-Wistar rats by the administration of a monoclonal antibody against the mesangial cell membrane antigen Thy 1.1. An acute drop in renal blood flow (RBF) and glomerular filtration rate (GFR) occurred within one hour of injury.RESULTS:
Pretreatment of animals with the cytokine inhibitor SKF 86002 prevented this drop. SKF 86002 had no effect on glomerular synthesis of vasoconstrictor eicosanoids.CONCLUSIONS:
The observations indicate that in mesangial cell immune injury, cytokines mediate renal hemodynamic impairment.
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Base de dados:
MEDLINE
Assunto principal:
Circulação Renal
/
Tiazóis
/
Anti-Inflamatórios não Esteroides
/
Citocinas
/
Mesângio Glomerular
/
Imidazóis
Limite:
Animals
Idioma:
En
Revista:
J Investig Med
Assunto da revista:
MEDICINA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos