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Genetic aberrations in adrenocortical tumors detected using comparative genomic hybridization correlate with tumor size and malignancy.
Kjellman, M; Kallioniemi, O P; Karhu, R; Höög, A; Farnebo, L O; Auer, G; Larsson, C; Bäckdahl, M.
Afiliação
  • Kjellman M; Department of Surgery, Karolinska Hospital, Stockholm, Sweden. kmak@kir.ks.se
Cancer Res ; 56(18): 4219-23, 1996 Sep 15.
Article em En | MEDLINE | ID: mdl-8797595
The differentiation between malignant and benign adrenocortical tumors is often difficult, and better markers are required. Because the genetic background of adrenocortical tumors is poorly characterized, we used comparative genomic hybridization (CGH) to screen for DNA sequence copy number changes in 8 sporadic primary adrenocortical cancers and 14 adenomas. There was a strong relationship between the number of genetic aberrations detected using CGH and both tumor size and malignancy. No alterations were seen in the smaller adenomas (< 5 cm), whereas the two largest adenomas (5 cm each) and seven of the eight cancers (7-20 cm) showed an increased number of genetic alterations. The presence of genetic aberrations detected using CGH was associated with an aneuploid DNA pattern. In the cancers, losses most often involved the chromosomal regions 2, 11q, and 17p (four of eight tumors), whereas gains took place at chromosomes 4 and 5 (four of eight tumors). In conclusion, our data indicate that genetic changes may help to define the malignant potential of adrenocortical tumors. Furthermore, the CGH results implicate several chromosomal regions that may contain genes with an important role in the development of adrenocortical cancers.
Assuntos
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Base de dados: MEDLINE Assunto principal: Adenoma / Aberrações Cromossômicas / Deleção Cromossômica / Neoplasias do Córtex Suprarrenal Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Res Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Suécia
Buscar no Google
Base de dados: MEDLINE Assunto principal: Adenoma / Aberrações Cromossômicas / Deleção Cromossômica / Neoplasias do Córtex Suprarrenal Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Res Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Suécia