Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma.
Cancer Res
; 56(19): 4351-3, 1996 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-8813122
ABSTRACT
DPC4, a recently cloned gene located on 18q2l.l, is inactivated in almost one half of pancreatic adenocarcinomas. To determine whether DPC4 inactivation is involved in esophageal adenocarcinoma, we have analyzed aneuploid populations from biopsies of 35 patients with Barrett's esophagus who had premalignant epithelium, adenocarcinoma, or both. Sixteen of 35 patients (46%) had allelic loss at l8q21.1, including 7 patients who had only premalignant tissue present in their Barrett segment. In addition, three of four patients (75%) with l8q21.1 loss in their aneuploid populations had the allelic loss present in diploid cells. Mutational analysis of DPC4 did not reveal any inactivating alterations in the gene. These data indicate that allelic losses at l8q are selected during neoplastic progression in Barrett's esophagus, but the targeted gene remains to be identified.
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Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
/
Esôfago de Barrett
/
Cromossomos Humanos Par 18
/
Neoplasias Esofágicas
/
Transativadores
/
Proteínas de Ligação a DNA
/
Alelos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos