[Derivatives of 1,3-bis-(methlendioxyphenoxy)propane with antispastic activity]. / Derivati dell'1,3-bis-(3,4-metilendiossifenossi)propano ad attività antispastica.
Farmaco Sci
; 32(7): 502-11, 1977 Jul.
Article
em It
| MEDLINE
| ID: mdl-891905
ABSTRACT
A number of amines derived from 1,3-bis(3,4-methylen-dioxyphenoxy)propane have been prepared from 1,3-bis-(3,4-methylendioxy-phenoxy)propan-2-one. The acute toxicity and the activity of these compounds on isolated guinea pig ileum have been studied. The majority of the compounds showed clear antagonist activity towards BaCl2, histamine and acetylcholine contracting responses, generally grater than that of papaverine; on the contrary, their antagonist activity towards 5-HT responses was slightly lower.
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Base de dados:
MEDLINE
Assunto principal:
Parassimpatolíticos
/
Propilaminas
Limite:
Animals
Idioma:
It
Revista:
Farmaco Sci
Ano de publicação:
1977
Tipo de documento:
Article