An in vivo proton magnetic resonance spectroscopy study of schizophrenia patients.
Schizophr Bull
; 22(4): 597-609, 1996.
Article
em En
| MEDLINE
| ID: mdl-8938914
ABSTRACT
The level of the 1H metabolites in the left dorsolateral prefrontal region of schizophrenia patients at different stages of illness were measured in vivo using a short echo time spectroscopy technique. During both the early onset and chronic stages, normal N-acetylaspartate levels were observed, which suggests that these patients had no significant neuronal cell damage and/or loss. The in vivo measurements of glutamate in the first-episode, drugnaive patients failed to provide convincing evidence for the involvement of the glutamatergic system in the dorsolateral prefrontal region. Significant differences in the glutamine levels were observed in the acutely medicated and chronic patients; however, the interpretation of these differences requires further study.
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Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Imageamento por Ressonância Magnética
/
Espectroscopia de Ressonância Magnética
/
Córtex Pré-Frontal
/
Ácido Aspártico
/
Ácido Glutâmico
/
Glutamina
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Schizophr Bull
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Canadá