Increased natural killer cells in fluids. A new, sensitive means of detecting carcinoma.
Acta Cytol
; 40(6): 1240-5, 1996.
Article
em En
| MEDLINE
| ID: mdl-8960035
ABSTRACT
OBJECTIVE:
Natural killer (NK) cells are cells of undefined lineage that are capable of lysing certain tumor cell lines in vitro. Determination of NK cell percent (NK%) in effusions by flow cytometry could aid in the detection of malignancies. STUDYDESIGN:
Over a six-month period at the Houston Veterans Affairs Medical Center, fresh effusions were routinely processed for cytology, and a portion was submitted for lymphocyte immunophenotyping using the FACScan and a panel including CD16/CD56 for NK cells. Seventy fluids (42 pleural, 28 peritoneal) from 62 men were examined.RESULTS:
NK cell percents were markedly increased in 15 cases (29-68%, mean 45.5) and low in 55 (2-20%, mean 8). Fourteen of the 15 cases with increased NK% were positive for carcinoma (93%), while 54/55 cases with low ones were negative for carcinoma (98%). Mesotheliomas, lymphomas and leukemias had low NK%.CONCLUSION:
Using the Mann-Whitney U test, an increase in NK% predicts metastatic carcinoma with a P level of < .00001.
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Base de dados:
MEDLINE
Assunto principal:
Líquido Ascítico
/
Carcinoma
/
Células Matadoras Naturais
/
Derrame Pleural Maligno
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Cytol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos