Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder.
Arch Dermatol
; 132(12): 1464-70, 1996 Dec.
Article
em En
| MEDLINE
| ID: mdl-8961876
ABSTRACT
OBJECTIVE:
To test the recent hypothesis that lymphomatoid granulomatosis (LYG) is a clonal B-cell proliferative process related to Epstein-Barr virus (EBV). BACKGROUND ANDDESIGN:
Historically, LYG has been classified as an angiocentric T-cell lymphoproliferative disorder. To further characterize LYG in the skin, we analyzed for EBV RNA in lymphocytes using in situ hybridization, coupled with colabeling for B-cell and T-cell markers. Clonality of lymphocytes was assessed by polymerase chain reaction using primers for immunoglobulin heavy chain genes and T-cell receptor beta and gamma genes.SETTING:
Academic referral center. PATIENTS In a 5-year retrospective review, we identified 4 patients with classic clinical and pathologic features of LYG in skin and lung, and tissue available from both sites. MAIN OUTCOMEMEASURES:
The presence or absence of EBV RNA and clonal gene rearrangements in cutaneous and pulmonary lesions of LYG.RESULTS:
Biopsy specimens of skin and lung in all patients revealed angiocentric infiltrates predominantly composed of T lymphocytes. Epstein-Barr virus RNA was identified in the skin of 1 patient and the lung of 3 patients, and was restricted to B cells. Polymerase chain reaction revealed clonal immunoglobulin heavy chain gene rearrangements and no clonal rearrangement of T-cell receptor genes in skin and lung tissue of all patients.CONCLUSIONS:
At least some examples of LYG in the skin and lung are characterized by a clonal proliferation of B lymphocytes, some of which contain EBV RNA. The B cells are typically scarce and may be obscured by striking angiocentric T-cell infiltrates.
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Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
/
Linfócitos B
/
Linfócitos T
/
Pneumopatias
/
Granulomatose Linfomatoide
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Dermatol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos