Dietary supplementation with L-arginine: modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer.
Br J Surg
; 84(2): 238-41, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9052446
ABSTRACT
BACKGROUND:
Dietary supplementation with L-arginine enhances natural cytotoxicity in peripheral blood lymphocytes but its effect on infiltrating lymphoreticular cells within a tumour microenvironment is unknown. The effects of dietary supplementation with L-arginine on tumour-infiltrating lymphocytes (TILs) in patients with colorectal cancer were evaluated.METHODS:
Eighteen patients received either a standard hospital diet (controls) or a standard diet supplemented with 30 g per day of L-arginine for 3 days before surgery. Tumour biopsies were taken at surgery and lymphocyte subsets (CD antigens) and macrophages examined immunohistochemically.RESULTS:
Tumours from patients receiving L-arginine contained increased numbers of specific cell subsets within the tumour which expressed CD16 (P = 0.004) and CD56 (P = 0.001) surface markers, when compared with tumours from control patients. There were no differences in the total number of T and B cells, T helper and T suppressor cells.CONCLUSION:
Dietary supplementation with L-arginine significantly alter the spectrum of TILs in human colorectal cancers in vivo. These findings have important implications for new strategies in anticancer treatment.
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Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Neoplasias Colorretais
/
Linfócitos do Interstício Tumoral
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Aged80
/
Humans
/
Middle aged
Idioma:
En
Revista:
Br J Surg
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Reino Unido