Gallstones in a community free of obesity but prone to slow intestinal transit.
Eur J Gastroenterol Hepatol
; 9(2): 201-6, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9058635
ABSTRACT
OBJECTIVES:
To verify anecdotal reports that gallstones were frequent in a remote community where obesity is rare and to look for possible explanations of their occurrence, including slow intestinal transit.DESIGN:
Population survey of gallbladder status and stool form.SETTING:
Two villages in Ladakh, a mountainous region of northern India; for comparison, a stratified random sample from general practitioners' lists in East Bristol.SUBJECTS:
Women aged 25-59 years, 437 in Ladakh and 974 in Bristol. MAIN OUTCOMEMEASURES:
Presence of gallstones on ultrasonography and response to questionnaires about parity, the intake of dried legume seeds (pulses) and bowel function including the form or appearance of the stools on a seven-point, transit-sensitive scale. Weight, height and waist circumference were also recorded.RESULTS:
Gallstone disease was at least as frequent in Ladakh as in Bristol although Ladakhi women were uniformly slim and their weight, waist size and body mass index failed to rise with age. After adjustment for age, gallstone disease was associated with higher body mass index and waist size in Bristol but not in Ladakh. It was associated with increased parity in Bristol, but not significantly so after adjusting for age and not at all in Ladakh. Gallstone disease was not directly associated with bowel function but Ladakhis often reported their stools to be lumpy (42.4 vs. 26.5% of Bristol women) and seldom as soft or loose (6.4 vs. 42.5%), implying that their intestinal transit tends to be slow.CONCLUSION:
Gallstones can be common in a population free of obesity but prone to intestinal stasis.
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Base de dados:
MEDLINE
Assunto principal:
Colelitíase
/
Motilidade Gastrointestinal
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
País/Região como assunto:
Asia
/
Europa
Idioma:
En
Revista:
Eur J Gastroenterol Hepatol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Reino Unido